AustralieFrV1, Main, Exploration, bibRecord, 003265

A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates

Identifieur interne : 003265 ( Main/Exploration ); précédent : 003264; suivant : 003266

A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates

Auteurs : Oleg V. Pyankov [Russie] ; Sergey A. Bodnev [Russie] ; Olga G. Pyankova [Russie] ; Vladislav V. Solodkyi [Russie] ; Stepan A. Pyankov [Russie] ; Yin Xiang Setoh ; Valentina A. Volchkova [France] ; Andreas Suhrbier [Australie] ; Viktor V. Volchkov [France] ; Alexander A. Agafonov [Russie] ; Alexander A. Khromykh

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2015.

RBID : PMC:4564530

Descripteurs français

English descriptors

KwdEn :
- Africa, Western, Animals, Cercopithecus aethiops, Ebola Vaccines (immunology), Ebolavirus (immunology), Glycoproteins (immunology), Hemorrhagic Fever, Ebola (immunology), Immunization (methods), Primates, Replicon (immunology), Vaccines, Virus-Like Particle (immunology), Viral Proteins (immunology), West Nile virus (immunology).
MESH :
- chemical , immunology : Ebola Vaccines, Glycoproteins, Vaccines, Virus-Like Particle, Viral Proteins.
- geographic : Africa, Western.
- immunology : Ebolavirus, Hemorrhagic Fever, Ebola, Replicon, West Nile virus.
- methods : Immunization.
- Animals, Cercopithecus aethiops, Primates.

Abstract

The current unprecedented outbreak of Ebola virus (EBOV) disease in West Africa has demonstrated the urgent need for a vaccine. Here, we describe the evaluation of an EBOV vaccine candidate based on Kunjin replicon virus-like particles (KUN VLPs) encoding EBOV glycoprotein with a D637L mutation (GP/D637L) in nonhuman primates. Four African green monkeys (Cercopithecus aethiops) were injected subcutaneously with a dose of 10⁹ KUN VLPs per animal twice with an interval of 4 weeks, and animals were challenged 3 weeks later intramuscularly with 600 plaque-forming units of Zaire EBOV. Three animals were completely protected against EBOV challenge, while one vaccinated animal and the control animal died from infection. We suggest that KUN VLPs encoding GP/D637L represent a viable EBOV vaccine candidate.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564530

DOI: 10.1093/infdis/jiv019
PubMed: 25732811
PubMed Central: 4564530

Affiliations:

Australie, France, Russie

Le document en format XML

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<term>Ebolavirus (immunology)</term>
<term>Glycoproteins (immunology)</term>
<term>Hemorrhagic Fever, Ebola (immunology)</term>
<term>Immunization (methods)</term>
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<term>Fièvre hémorragique à virus Ebola (immunologie)</term>
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<term>Immunisation ()</term>
<term>Primates</term>
<term>Protéines virales (immunologie)</term>
<term>Réplicon (immunologie)</term>
<term>Vaccins contre la maladie à virus Ebola (immunologie)</term>
<term>Vaccins à pseudo-particules virales (immunologie)</term>
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<front><div type="abstract" xml:lang="en"><p>The current unprecedented outbreak of Ebola virus (EBOV) disease in West Africa has demonstrated the urgent need for a vaccine. Here, we describe the evaluation of an EBOV vaccine candidate based on Kunjin replicon virus-like particles (KUN VLPs) encoding EBOV glycoprotein with a D637L mutation (GP/D637L) in nonhuman primates. Four African green monkeys (<italic>Cercopithecus aethiops</italic>
) were injected subcutaneously with a dose of 10<sup>9</sup>
 KUN VLPs per animal twice with an interval of 4 weeks, and animals were challenged 3 weeks later intramuscularly with 600 plaque-forming units of Zaire EBOV. Three animals were completely protected against EBOV challenge, while one vaccinated animal and the control animal died from infection. We suggest that KUN VLPs encoding GP/D637L represent a viable EBOV vaccine candidate.</p>
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<country name="Australie"><noRegion><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name>
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</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003265 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003265 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4564530
   |texte=   A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25732811" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates

A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates

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Descripteurs français

English descriptors

Abstract

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Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
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